Regulated delivery of molecular cargo to invasive tumour-derived microvesicles.

Regulated Delivery of Molecular Cargo to Invasive Tumor-derived Microvesicles

Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers.

Recent advances in the study of tumor-derived microvesicles reveal new insights into the cellular basis of disease progression and the potential to translate this knowledge into innovative approaches for cancer diagnostics and personalized therapy. Tumor-derived microvesicles are heterogeneous membrane-bound sacs that are shed from the surfaces of tumor cells into the extracellular environment....

Biology and biogenesis of shed microvesicles

The ability of cells to transmit bioactive molecules to recipient cells and the extracellular environment is a fundamental requirement for both normal physiology and disease pathogenesis. It has traditionally been thought that soluble factors released from cells were responsible for this cellular signaling but recent research has revealed a fundamental role for microvesicles in this process. Mi...

ارزیابی آنژیوژنز در کارسینوم سلولهای بازال و کارسینوم سلولهای سنگفرشی پوست

    Background & Aim: Tumour angiogenesis is essential for tumour growth and appears to play an important role both in invasive growth and metastasis. Basal cell carcinomas(BCCs) and squamous cell carcinomas(SCCs) of the skin are derived from a similar cell type but differ in the invasive and metastatic potential. This study investigates whether the behaviour of these tumours could be explained...

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

BACKGROUND Increased mitogen-activated protein kinase (MAPK) signaling, small GTPase activation, cytoskeletal rearrangements, and the directed targeting of proteases to sites of extracellular matrix degradation all accompany the process of tumor cell invasion. Several studies have implicated the small GTP-binding protein ARF6 in tumor cell invasion, although the molecular basis by which ARF6 fa...